Our lab studies the mechanisms by which blood flow regulates endothelial biology and dysfunction, which leads to atherosclerosis and aortic valve disease.

In addition to in vitro systems, our lab also developed an in vivo model (the mouse partial carotid ligation) to use in conjunction with OMICs approaches to understand how disturbed flow vs. stable flow differently regulate vascular and valvular endothelial biology and pathobiology at the genome-, epigenome-, and metabolome-wide level. These studies have allowed us to not only identify mechanosensitive genes, metabolic, and epigenetic changes, but also to demonstrate the critical role that some of these flow-sensitive molecular transducers play in controlling endothelial biology, atherosclerosis, and aortic valve disease.

Location

Emory University

1760 Haygood Drive NE
Atlanta, GA 30322
HSRB Room E-197

Contact

Hanjoong Jo, PhD
Principal Investigator
hanjoong.jo@bme.gatech.edu

Colleen Spellen
Administrative Assistant to Dr. Jo
cspelle@emory.edu

(404) 712-9136

We announce the Gordon Research Conference 2023 on Biomechanics in Vascular Biology and Disease.
At this inaugural GRC on Biomechanics meeting, engineers, biomedical scientists, & clinicians will gather to address the role of biomechanics and mechanobiology in cardiovascular biology & medicine.

Applications must be submitted by July 9, 2023

Mount Holyoke College, MA, USA
August 6-11, 2023

Jo Lab News

Ian Tamargo, Kyung Baek, Yerin Kim & Christian Park Team in @JoLab publishes @NatureReviewsCardiology paper (https://rdcu.be/dcSUZ). Here, we discuss the emerging concept of disturbed Flow-Induced Reprogramming of ECs (FIRE), EndMT & Endo-Immune-Transition.

A postdoctoral position is available immediately to study how flow regulates vascular or valvular biology and disease. This fellow will conduct scRNAseq, scATACseq, and mechanobiological studies using in vivo and in vitro systems to define how flow regulates atherosclerosis and aortic valve disease. Also, RNA-based therapeutics and targeted delivery studies will be conducted by the fellow in the Department of Biomedical Engineering at Emory University in Atlanta, Georgia, USA. We are looking for a motivated and talented biomedical scientist or engineer with a Ph.D. or MD in related fields and a strong publication record.

Please send your CV by e-mail to Professor Hanjoong Jo at hjo@emory.edu.

Applications will be reviewed on a rolling basis until filled.